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amyotrophic lateral sclerosis, autosomal recessive, with or without frontotemporal dementia
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Cancer Gene Census
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FUS
Somatic tumors
liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma
Tumor types germline
Cancer Syndrom
Translocation partner
DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1, NFATC2
Name
fusion, derived from t(12;16) malignant liposarcoma
Chromosome banding
16p11.2
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Definition
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PubMed Links
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FUS
Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3
Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes
The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties
Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode
Domain architectures and characterization of an RNA-binding protein, TLS
A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP
Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry
Clinical Trials
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