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brooke-spiegler syndrome
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CYLD
Somatic tumors
cylindroma
Tumor types germline
cylindroma
Cancer Syndrom
familial cylindromatosis, familial trichoepithelioma, Brooke-Spiegler syndrome
Translocation partner
Name
familial cylindromatosis gene
Chromosome banding
16q12-q13
Cancer molecular gen.
Rec
Mutation type
Mis, N, F, S
Other syndrome disease
Definition
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CYLD
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination