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dementia, frontotemporal
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PSEN1
Endoproteolytic processing and stabilization of wild-type and mutant presenilin
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
Presenilin endoproteolysis is an intramolecular cleavage
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
MAPT
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens
Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications
Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau
Untangling the tau gene association with neurodegenerative disorders
Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease
Hereditary frontotemporal dementia caused by Tau gene mutations
Cancer Gene Census
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Definition
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Pathways
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Wnt signaling pathway
Homo sapiens (human)
one gene
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External
The Chinese Familial Alzheimer's Network (CFAN)