Medical Knowledge Cockpit malaria, cerebral, susceptibility to

• Antigen processing and presentation
  Homo sapiens (human) one gene

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• Cell adhesion molecules (CAMs)
  Homo sapiens (human) one gene

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• Osteoclast differentiation
  Homo sapiens (human) one gene

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• TGF-beta signaling pathway
  Homo sapiens (human) one gene

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CD36

• Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake
• Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages
• Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns
• Thrombospondin induces dimerization of membrane-bound, but not soluble CD36
• Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2

• Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis
• CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

ICAM1

• Targeting leukocyte integrins in human diseases
• The role of ICAM-1 in Plasmodium falciparum cytoadherence
• ICAM-1 co-stimulates target cells to facilitate antigen presentation

TNF

• Regulation of proliferation, survival and apoptosis by members of the TNF superfamily
• Dynamic dissociating homo-oligomers and the control of protein function
• Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1
• Regulation of bitter taste responses by tumor necrosis factor