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mast cell disease
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Pathways
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Cancer Gene Census
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KIT
Somatic tumors
GIST, AML, TGCT, mastocytosis, mucosal melanoma
Tumor types germline
GIST, epithelioma
Cancer Syndrom
familial gastrointestinal stromal tumour
Translocation partner
Name
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Chromosome banding
4q12
Cancer molecular gen.
Dom
Mutation type
Mis, O
Other syndrome disease
Piebald trait
Definition
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PubMed Links
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KIT
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway
A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses
Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor
Clinical Trials
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External
Study of Factors Regulating Mast Cell Proliferation