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obesity, morbid, due to leptin deficiency
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LEP
Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity
The effects of high fat diets on the blood-brain barrier transport of leptin: failure or adaptation?
Overfeeding rapidly induces leptin and insulin resistance
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
Minireview: nutrient sensing and the regulation of insulin action and energy balance
Revisiting leptin's role in obesity and weight loss
Leptin therapy gains FDA approval
Metreleptin: first global approval
Crystal structure of the obese protein leptin-E100
Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications
Advances in understanding the interrelations between leptin resistance and obesity
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation
Molecular mapping of the mouse ob mutation
Positional cloning of the mouse obese gene and its human homologue
Genetic variation and nutrition in obesity: approaches to the molecular genetics of obesity
Molecular mapping of the mouse db mutation
Cancer Gene Census
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Definition
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Pathways
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Clinical Trials
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External
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance