Medical Knowledge Cockpit renal cell carcinoma, papillary

TFE3

• Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
• A high-frequency RFLP at the human TFE3 locus on the X chromosome
• The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22

MET

• Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
• MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2)
• Clear cell carcinoma of the ovary: a review of the literature
• Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
• A genetic variant that disrupts MET transcription is associated with autism

• Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions
• A familial heterozygous null mutation of MET in autism spectrum disorder
• MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus
• Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus
• A new synaptic player leading to autism risk: Met receptor tyrosine kinase
• Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase
• Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain

PRCC

• The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene

MET

Somatic tumors

papillary renal, head-neck squamous cell

Tumor types germline

papillary renal

Cancer Syndrom

familial papillary renal cancer

Translocation partner

Name

met proto-oncogene (hepatocyte growth factor receptor)

Chromosome banding

7q31

Cancer molecular gen.

Dom

Mutation type

Mis

Other syndrome disease