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AUH

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common elementfound in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulatingfactor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologousto enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsichydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzymeactivity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog ofthis protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novelrole as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb,and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. (providedby RefSeq, May 2010)

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common elementfound in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulatingfactor

ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologousto enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsichydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzymeactivity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog ofthis protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novelrole as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb,and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. (providedby RefSeq, May 2010)

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  • Valine, leucine and isoleucine degradation
    Homo sapiens (human) one gene
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