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MDM2

Somatic tumors
sarcoma, glioma, colorectal, other tumour types
Tumor types germline
Cancer Syndrom
Translocation partner
Name
Mdm2 p53 binding protein homolog
Chromosome banding
12q15
Cancer molecular gen.
Dom
Mutation type
A
Other syndrome disease
Definition     No results

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MDM2

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation bytargeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itselftranscriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety ofdifferent cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in amultitude of transcript variants, many of which may be expressed only in tumor cells. (provided by RefSeq, Jun2013)

This gene encodes a nuclear-localized E3 ubiquitin ligase

The encoded protein can promote tumor formation bytargeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itselftranscriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety ofdifferent cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in amultitude of transcript variants, many of which may be expressed only in tumor cells. (provided by RefSeq, Jun2013)

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