Add Custom Markers
PubMed Links     No results

An error occurred

Cancer Gene Census     No results

An error occurred

PRKAR1A

Somatic tumors
papillary thyroid
Tumor types germline
myxoma, endocrine, papillary thyroid
Cancer Syndrom
Carney complex
Translocation partner
RET
Name
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
Chromosome banding
17q23-q24
Cancer molecular gen.
Dom/Rec
Mutation type
T, Mis, N, F, S
Other syndrome disease
Pathways     No results

An error occurred

  • Apoptosis
    Homo sapiens (human) one gene
Clinical Trials     No results

An error occurred

Please search a gene to see results here
Definition     No results

An error occurred

PRKAR1A

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activatingthe cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different targetproteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMPand two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits havebeen identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be atissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblasthybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by generearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclearlocalization sequence (NLS) has been found for this protein which suggests a role in DNA replication via theprotein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).Several alternatively spliced transcript variants encoding two different isoforms have been observed. (providedby RefSeq, Jan 2013)

cAMP is a signaling molecule important for a variety of cellular functions

cAMP exerts its effects by activatingthe cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different targetproteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMPand two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits havebeen identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be atissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblasthybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by generearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclearlocalization sequence (NLS) has been found for this protein which suggests a role in DNA replication via theprotein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).Several alternatively spliced transcript variants encoding two different isoforms have been observed. (providedby RefSeq, Jan 2013)