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EGFR

Cancer Gene Census     No results

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EGFR

Somatic tumors
glioma, NSCLC
Tumor types germline
NSCLC
Cancer Syndrom
familial lung cancer
Translocation partner
Name
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Chromosome banding
7p12.3-p12.1
Cancer molecular gen.
Dom
Mutation type
A, O, Mis
Other syndrome disease
Definition     No results

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EGFR

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinasesuperfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surfaceprotein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerizationand tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lungcancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been foundfor this gene. (provided by RefSeq, Jul 2010)

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinasesuperfamily

This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surfaceprotein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerizationand tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lungcancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been foundfor this gene. (provided by RefSeq, Jul 2010)

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