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Cancer Gene Census     No results

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BRAF

Somatic tumors
melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour, pancreas acinar carcinoma, melanocytic nevus, prostate, gastric
Tumor types germline
Cancer Syndrom
Translocation partner
AKAP9, KIAA1549, CEP88, LSM14A, SND1, FCHSD1, SLC45A3, FAM131B, RNF130, CLCN6, MKRN1, GNAI1, AGTRAP
Name
v-raf murine sarcoma viral oncogene homolog B1
Chromosome banding
7q34
Cancer molecular gen.
Dom
Mutation type
Mis, T, O
Other syndrome disease
Cardio-facio-cutaneous syndrome
Definition     No results

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ERBB2

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Thisprotein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bindtightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding andenhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activatedprotein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 ofisoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, includingbreast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encodingdifferent isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008)

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases

Thisprotein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bindtightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding andenhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activatedprotein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 ofisoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, includingbreast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encodingdifferent isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008)

Pathways     No results

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  • Neurotrophin signaling pathway
    Homo sapiens (human) one gene
  • Long-term potentiation
    Homo sapiens (human) one gene
  • Natural killer cell mediated cytotoxicity
    Homo sapiens (human) one gene
  • Adherens junction
    Homo sapiens (human) one gene
Clinical Trials     No results

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