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ERBB2

Somatic tumors
breast, ovarian, other tumour types, NSCLC, gastric
Tumor types germline
Cancer Syndrom
Translocation partner
Name
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Chromosome banding
17q21.1
Cancer molecular gen.
Dom
Mutation type
A, Mis, O
Other syndrome disease
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Definition     No results

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BRAF

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases

This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

Pathways     No results

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  • Melanoma
    Homo sapiens (human) one gene
  • Thyroid cancer
    Homo sapiens (human) one gene
  • Glioma
    Homo sapiens (human) one gene
  • Renal cell carcinoma
    Homo sapiens (human) one gene