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Pathways     No results

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  • mcalpain and friends in cell motility
    species not specified one gene
  • angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
    species not specified one gene
  • Chemokine signaling pathway
    Homo sapiens (human) one gene
  • Acute myeloid leukemia
    Homo sapiens (human) one gene
  • Chronic myeloid leukemia
    Homo sapiens (human) one gene
  • PI3K-Akt signaling pathway
    Homo sapiens (human) one gene
Definition     No results

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BRAF

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases

This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

Cancer Gene Census     No results

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BRAF

Somatic tumors
melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour, pancreas acinar carcinoma, melanocytic nevus, prostate, gastric
Tumor types germline
Cancer Syndrom
Translocation partner
AKAP9, KIAA1549, CEP88, LSM14A, SND1, FCHSD1, SLC45A3, FAM131B, RNF130, CLCN6, MKRN1, GNAI1, AGTRAP
Name
v-raf murine sarcoma viral oncogene homolog B1
Chromosome banding
7q34
Cancer molecular gen.
Dom
Mutation type
Mis, T, O
Other syndrome disease
Cardio-facio-cutaneous syndrome