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EGFR

Cancer Gene Census     No results

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BRAF

Somatic tumors
melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour, pancreas acinar carcinoma, melanocytic nevus, prostate, gastric
Tumor types germline
Cancer Syndrom
Translocation partner
AKAP9, KIAA1549, CEP88, LSM14A, SND1, FCHSD1, SLC45A3, FAM131B, RNF130, CLCN6, MKRN1, GNAI1, AGTRAP
Name
v-raf murine sarcoma viral oncogene homolog B1
Chromosome banding
7q34
Cancer molecular gen.
Dom
Mutation type
Mis, T, O
Other syndrome disease
Cardio-facio-cutaneous syndrome
Definition     No results

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BRAF

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases

This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

Pathways     No results

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  • Thyroid cancer
    Homo sapiens (human) one gene
  • Vascular smooth muscle contraction
    Homo sapiens (human) one gene
  • Dorso-ventral axis formation
    Homo sapiens (human) one gene
  • Gap junction
    Homo sapiens (human) one gene
  • Renal cell carcinoma
    Homo sapiens (human) one gene
  • Colorectal cancer
    Homo sapiens (human) one gene
Clinical Trials     No results

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