Medical Knowledge Cockpit adenocarcinoma

 

• Non-small cell lung cancer
  Homo sapiens (human) 3 genes

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• Prostate cancer
  Homo sapiens (human) 3 genes

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• Focal adhesion
  Homo sapiens (human) 3 genes

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• ErbB signaling pathway
  Homo sapiens (human) 3 genes

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• Endometrial cancer
  Homo sapiens (human) 3 genes

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• Pancreatic cancer
  Homo sapiens (human) 3 genes

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EGFR

Somatic tumors

glioma, NSCLC

Tumor types germline

NSCLC

Cancer Syndrom

familial lung cancer

Translocation partner

Name

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Chromosome banding

7p12.3-p12.1

Cancer molecular gen.

Dom

Mutation type

A, O, Mis

Other syndrome disease

 

EGFR

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinasesuperfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surfaceprotein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerizationand tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lungcancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been foundfor this gene. (provided by RefSeq, Jul 2010)

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinasesuperfamily

This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surfaceprotein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerizationand tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lungcancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been foundfor this gene. (provided by RefSeq, Jul 2010)

 

EGFR

• UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug
• Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells
• The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor
• A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells
• The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

• ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
• Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland
• The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin
• Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
• Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor
• The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
• Identification of Nck family genes, chromosomal localization, expression, and signaling specificity
• Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

 

BRAF

• Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
• Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
• Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members
• Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

• The cardiofaciocutaneous syndrome

ERBB2

• Analysis of Her2/neu membrane protein clusters in different types of breast cancer cells using localization microscopy
• Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer
• ERBB2 regulation by Estrogen Receptor-Pax2 determines tamoxifen response
• Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

RAD54L

• Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation

MSR1

• Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions