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External
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ERBB2
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ASCC1
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is atranscriptional coactivator that plays an important role in gene transactivation by multiple transcriptionfactors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF).The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivationby the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma.Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. (provided byRefSeq, Dec 2011)This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex
The ASC-1 complex is atranscriptional coactivator that plays an important role in gene transactivation by multiple transcriptionfactors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF).The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivationby the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma.Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. (provided byRefSeq, Dec 2011)
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EGFR
BRAF
ERBB2