Medical Knowledge Cockpit adenocarcinoma

 

EGFR

• Quantitative methods for the analysis of protein phosphorylation in drug development
• Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials
• Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis
• Management of EGFR-inhibitor associated rash: a retrospective study in 49 patients
• Mechanisms of cutaneous toxicities to EGFR inhibitors

• EGF receptor (EGFR) signaling promoting invasion is disrupted in androgen-sensitive prostate cancer cells by an interaction between EGFR and androgen receptor (AR)
• The androgen receptor associates with the epidermal growth factor receptor in androgen-sensitive prostate cancer cells
• ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation
• Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
• A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation
• Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
• Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
• cbl-b inhibits epidermal growth factor receptor signaling

 

BRAF

• Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification
• Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
• Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
• Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

• Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

ERBB2

• Utility of serum HER2 extracellular domain assessment in clinical decision making: pooled analysis of four trials of trastuzumab in metastatic breast cancer
• ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
• Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription
• c-erbB-2 gene product directly associates with beta-catenin and plakoglobin

RAD54L

• Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation

MSR1

• Lipid accumulation and dendritic cell dysfunction in cancer

 

BRAF

Somatic tumors

melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour, pancreas acinar carcinoma, melanocytic nevus, prostate, gastric

Tumor types germline

Cancer Syndrom

Translocation partner

AKAP9, KIAA1549, CEP88, LSM14A, SND1, FCHSD1, SLC45A3, FAM131B, RNF130, CLCN6, MKRN1, GNAI1, AGTRAP

Name

v-raf murine sarcoma viral oncogene homolog B1

Chromosome banding

7q34

Cancer molecular gen.

Dom

Mutation type

Mis, T, O

Other syndrome disease

Cardio-facio-cutaneous syndrome

 

RAD54L

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity withSaccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA.This protein has been shown to play a role in homologous recombination related repair of DNA double-strandbreaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought tofacilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multipletranscript variants encoding the same protein.(provided by RefSeq, Dec 2008)

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity withSaccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA

This protein has been shown to play a role in homologous recombination related repair of DNA double-strandbreaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought tofacilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multipletranscript variants encoding the same protein.(provided by RefSeq, Dec 2008)

 

• Thyroid cancer
  Homo sapiens (human) one gene

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• Vascular smooth muscle contraction
  Homo sapiens (human) one gene

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• Dorso-ventral axis formation
  Homo sapiens (human) one gene

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• Gap junction
  Homo sapiens (human) one gene

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• Renal cell carcinoma
  Homo sapiens (human) one gene

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• Colorectal cancer
  Homo sapiens (human) one gene

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