Medical Knowledge Cockpit adenocarcinoma

 

• Pancreatic cancer
  Homo sapiens (human) 3 genes

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• Pathways in cancer
  Homo sapiens (human) 3 genes

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• Bladder cancer
  Homo sapiens (human) 3 genes

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• Glioma
  Homo sapiens (human) 2 genes

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• Melanoma
  Homo sapiens (human) 2 genes

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• Hepatitis C
  Homo sapiens (human) 2 genes

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ERBB2

Somatic tumors

breast, ovarian, other tumour types, NSCLC, gastric

Tumor types germline

Cancer Syndrom

Translocation partner

Name

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Chromosome banding

17q21.1

Cancer molecular gen.

Dom

Mutation type

A, Mis, O

Other syndrome disease

 

ASCC1

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is atranscriptional coactivator that plays an important role in gene transactivation by multiple transcriptionfactors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF).The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivationby the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma.Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. (provided byRefSeq, Dec 2011)

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex

The ASC-1 complex is atranscriptional coactivator that plays an important role in gene transactivation by multiple transcriptionfactors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF).The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivationby the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma.Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. (provided byRefSeq, Dec 2011)

 

EGFR

• ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
• Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland
• The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin
• Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
• Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor

• The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
• Identification of Nck family genes, chromosomal localization, expression, and signaling specificity
• Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways
• Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor
• EGF-dependent association of phospholipase C-gamma1 with c-Cbl
• Cytoskeletal association of epidermal growth factor receptor and associated signaling proteins is regulated by cell density in IEC-6 intestinal cells
• Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor
• Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

 

BRAF

• The cardiofaciocutaneous syndrome
• EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome
• Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
• Detection of BRAF V600E mutation by pyrosequencing
• BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status

• Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology

ERBB2

• Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer
• Utility of serum HER2 extracellular domain assessment in clinical decision making: pooled analysis of four trials of trastuzumab in metastatic breast cancer
• ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
• Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription

RAD54L

• Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation

MSR1

• Macrophage scavenger receptor confers an adherent phenotype to cells in culture