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APC

Somatic tumors
colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS
Tumor types germline
colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS
Cancer Syndrom
adenomatous polyposis coli; Turcot syndrome
Translocation partner
Name
adenomatous polyposis of the colon gene
Chromosome banding
5q21
Cancer molecular gen.
Rec
Mutation type
D, Mis, N, F, S
Other syndrome disease
Definition     No results

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APC

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is alsoinvolved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis.Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease thatusually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designatedthe mutation cluster region (MCR) and result in a truncated protein product. (provided by RefSeq, Jul 2008)

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway

It is alsoinvolved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis.Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease thatusually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designatedthe mutation cluster region (MCR) and result in a truncated protein product. (provided by RefSeq, Jul 2008)

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