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MUTYH

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases fromthe DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus andmitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multipletranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair

The enzyme excises adenine bases fromthe DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus andmitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multipletranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

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MUTYH

Somatic tumors
Tumor types germline
colorectal
Cancer Syndrom
adenomatous polyposis coli
Translocation partner
Name
mutY homolog (E. coli)
Chromosome banding
1p34.3-1p32.1
Cancer molecular gen.
Rec
Mutation type
Mis
Other syndrome disease