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MEN1

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1

In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

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MEN1

Somatic tumors
parathyroid tumours, pancreatic neuroendocrine tumour
Tumor types germline
parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid
Cancer Syndrom
multiple endocrine neoplasia type 1
Translocation partner
Name
multiple endocrine neoplasia type 1 gene
Chromosome banding
11q13
Cancer molecular gen.
Rec
Mutation type
D, Mis, N, F, S
Other syndrome disease
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