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Cancer Gene Census     No results

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TP53

Somatic tumors
breast, colorectal, lung, sarcoma, adrenocortical, glioma, Spitzoid tumour, multiple other tumour types
Tumor types germline
breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types
Cancer Syndrom
Li-Fraumeni syndrome
Translocation partner
NTRK1
Name
tumor protein p53
Chromosome banding
17p13
Cancer molecular gen.
Rec
Mutation type
Mis, N, F, T
Other syndrome disease
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Definition     No results

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TP53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, andoligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression oftarget genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such asLi-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multipletranscript variants and isoforms. Additional isoforms have also been shown to result from the use of alternatetranslation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, andoligomerization domains

The encoded protein responds to diverse cellular stresses to regulate expression oftarget genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such asLi-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multipletranscript variants and isoforms. Additional isoforms have also been shown to result from the use of alternatetranslation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

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TP53

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