Medical Knowledge Cockpit afibrinogenemia, congenital

FGA

• Structure and function of human fibrinogen inferred from dysfibrinogens
• New insights into fibrin (ogen) structure and function
• Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease

FGB

• Disulfide bridges in nh2 -terminal part of human fibrinogen.
• Abnormal fibrinogens IJmuiden (B beta Arg14----Cys) and Nijmegen (B beta Arg44----Cys) form disulfide-linked fibrinogen-albumin complexes.
• Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr.

• Complement and coagulation cascades
  Homo sapiens (human) 2 genes

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