Medical Knowledge Cockpit afibrinogenemia, congenital

FGA

• Potential role of entactin in hemostasis. Specific interaction of entactin with fibrinogen A alpha and B beta chains
• Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains
• Localization of the binding site of tissue-type plasminogen activator to fibrin

FGB

• Molecular mechanisms of hypo- and afibrinogenemia.
• New insights into fibrin (ogen) structure and function.
• Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease.

• Complement and coagulation cascades
  Homo sapiens (human) 2 genes

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