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agammaglobulinemia 7, autosomal recessive
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Cancer Gene Census
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PIK3R1
Somatic tumors
glioblastoma, ovarian, colorectal
Tumor types germline
Cancer Syndrom
Translocation partner
Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Chromosome banding
5q13.1
Cancer molecular gen.
Rec
Mutation type
Mis, F, O
Other syndrome disease
Pathways
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Definition
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PubMed Links
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PIK3R1
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2
A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners
Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation
Clinical Trials
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