Medical Knowledge Cockpit aids, slow progression to

CXCR1

• CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

IL4R

• Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation

 

• Chemokine signaling pathway
  Homo sapiens (human) one gene

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CXCR1

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptorfor interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-proteinactivated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonicoligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another highaffinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped tochromosome 2q33-q36. (provided by RefSeq, Jul 2008)

The protein encoded by this gene is a member of the G-protein-coupled receptor family

This protein is a receptorfor interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-proteinactivated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonicoligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another highaffinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped tochromosome 2q33-q36. (provided by RefSeq, Jul 2008)