Medical Knowledge Cockpit allergic rhinitis, susceptibility to

IL13

• The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes

 

IL13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine isinvolved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class IIexpression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity,thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to becritical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE andeosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this geneparticularly close to IL4. (provided by RefSeq, Jul 2008)

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells

This cytokine isinvolved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class IIexpression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity,thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to becritical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE andeosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this geneparticularly close to IL4. (provided by RefSeq, Jul 2008)