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alzheimer disease, type 3
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PSEN1
Endoproteolytic processing and stabilization of wild-type and mutant presenilin
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
Presenilin endoproteolysis is an intramolecular cleavage
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
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External
Longitudinal Early-onset Alzheimer's Disease Study Protocol (LEADS)