Medical Knowledge Cockpit alzheimer disease, type 3

PSEN1

• Endoproteolytic processing and stabilization of wild-type and mutant presenilin
• Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
• Presenilin endoproteolysis is an intramolecular cleavage
• Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

• Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity