Medical Knowledge Cockpit alzheimer disease, type 3

PSEN1

• Presenilin mutations in Alzheimer's disease
• Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene
• When loss is gain: reduced presenilin proteolytic function leads to increased A����42/A����40. Talking Point on the role of presenilin mutations in Alzheimer disease
• Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease
• Genetic linkage evidence for a familial Alzheimer's seasesease locus on chromosome 14

• Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease