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amyotrophic lateral sclerosis, autosomal recessive
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FUS
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator
Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR
PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays
Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
Cancer Gene Census
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FUS
Somatic tumors
liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma
Tumor types germline
Cancer Syndrom
Translocation partner
DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1, NFATC2
Name
fusion, derived from t(12;16) malignant liposarcoma
Chromosome banding
16p11.2
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Definition
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