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Pathways     No results

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  • HTLV-I infection
    Homo sapiens (human) 2 genes
  • cell cycle: g2/m checkpoint
    species not specified 2 genes
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    species not specified 2 genes
  • Homologous recombination repair of replication-independent double-strand breaks
    species not specified 2 genes
Clinical Trials     No results

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Definition     No results

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XRCC3

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombinationto maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamsterirs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents andis chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patientsof varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have beenidentified. (provided by RefSeq, Jul 2008)

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombinationto maintain chromosome stability and repair DNA damage

This gene functionally complements Chinese hamsterirs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents andis chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patientsof varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have beenidentified. (provided by RefSeq, Jul 2008)

Cancer Gene Census     No results

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PALB2

Somatic tumors
Tumor types germline
Wilms tumour, medulloblastoma, AML ,breast
Cancer Syndrom
Fanconi anaemia N, breast cancer susceptibility
Translocation partner
Name
partner and localizer of BRCA2
Chromosome banding
16p12.1
Cancer molecular gen.
Rec
Mutation type
F, N, Mis
Other syndrome disease
PubMed Links     No results

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