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  • Recruitment of repair and signaling proteins to double-strand breaks
    species not specified one gene
Definition     No results

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BRCA2

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovariancancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologousrecombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motifcalled the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair.BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss ofheterozygosity (LOH) of the wild-type allele. (provided by RefSeq, Dec 2008)

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovariancancer

Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologousrecombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motifcalled the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair.BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss ofheterozygosity (LOH) of the wild-type allele. (provided by RefSeq, Dec 2008)

Cancer Gene Census     No results

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BRCA2

Somatic tumors
breast, ovarian, pancreatic
Tumor types germline
breast, ovarian, pancreatic, leukaemia (FANCB, FANCD1)
Cancer Syndrom
hereditary breast/ovarian cancer
Translocation partner
Name
familial breast/ovarian cancer gene 2
Chromosome banding
13q12
Cancer molecular gen.
Rec
Mutation type
D, Mis, N, F, S
Other syndrome disease
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BRCA1

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