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BRCA2
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovariancancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologousrecombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motifcalled the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair.BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss ofheterozygosity (LOH) of the wild-type allele. (provided by RefSeq, Dec 2008)Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovariancancer
Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologousrecombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motifcalled the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair.BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss ofheterozygosity (LOH) of the wild-type allele. (provided by RefSeq, Dec 2008)
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BRCA2
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BRCA1
BRCA2
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