Medical Knowledge Cockpit c1s deficiency

C1R

• Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r
• Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides
• A common amino acid polymorphism in complement component C1R

C1S

• NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q
• Human genes for complement components C1r and C1s in a close tail-to-tail arrangement
• Synthesis and regulation of C1 inhibitor in human skin fibroblasts

• classical complement pathway
  species not specified 2 genes

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