Medical Knowledge Cockpit colorectal cancer, hereditary nonpolyposis, type 2

MLH1

• The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2
• The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer
• Clinicopathological relevance of the association between gastrointestinal and sebaceous neoplasms: the Muir-Torre syndrome.

MLH1

Somatic tumors

colorectal, endometrial, ovarian, CNS tumours

Tumor types germline

colorectal, endometrial, ovarian, CNS

Cancer Syndrom

hereditary non-polyposis colorectal cancer, Turcot syndrome

Translocation partner

Name

E.coli MutL homolog gene

Chromosome banding

3p21.3

Cancer molecular gen.

Rec

Mutation type

D, Mis, N, F, S

Other syndrome disease