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CYP2A6

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteinsare monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced byphenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1,nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poormetabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of alarge cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The genewas formerly referred to as CYP2A3; however, it has been renamed CYP2A6. (provided by RefSeq, Jul 2008)

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes

The cytochrome P450 proteinsare monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced byphenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1,nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poormetabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of alarge cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The genewas formerly referred to as CYP2A3; however, it has been renamed CYP2A6. (provided by RefSeq, Jul 2008)

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