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diabetes, type 2
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Pathways
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basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
species not specified
one gene
visceral fat deposits and the metabolic syndrome
species not specified
one gene
Clinical Trials
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External
Iloprost in Preventing Lung Cancer in Former Smokers
Definition
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Cancer Gene Census
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PPARG
Somatic tumors
follicular thyroid
Tumor types germline
Cancer Syndrom
Translocation partner
PAX8
Name
peroxisome proliferative activated receptor, gamma
Chromosome banding
3p25
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension
PubMed Links
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PAX4
Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue
Organisation of the human PAX4 gene and its exclusion as a candidate for the Wolcott-Rallison syndrome
KCNJ11
Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population
TCF7L2
The new type 2 diabetes gene TCF7L2
A gene family of HMG-box transcription factors with homology to TCF-1
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
MTNR1B
Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls
Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin
Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
PPARG
Honokiol: a non-adipogenic PPAR�� agonist from nature
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus