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diabetes mellitus, type 2
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Thyroid cancer
Homo sapiens (human)
one gene
PubMed Links
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PAX4
Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue
Organisation of the human PAX4 gene and its exclusion as a candidate for the Wolcott-Rallison syndrome
KCNJ11
Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population
TCF7L2
Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion
The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin
Tcf4 can specifically recognize beta-catenin using alternative conformations
Structure of a human Tcf4-beta-catenin complex
MTNR1B
Functional activity of serotoninergic and melatoninergic systems expressed in the skin
Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers
Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7
Cancer Gene Census
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TCF7L2
Somatic tumors
colorectal
Tumor types germline
Cancer Syndrom
Translocation partner
VTI1A
Name
transcription factor 7-like 2
Chromosome banding
10q25.3
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Clinical Trials
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Definition
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