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ectodermal dysplasia, anhidrotic
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NFKBIA
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain
IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2
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