Medical Knowledge Cockpit emberger syndrome

GATA2

Somatic tumors

AML (CML blast transformation)

Tumor types germline

Cancer Syndrom

Translocation partner

Name

GATA binding protein 2

Chromosome banding

3q21.3

Cancer molecular gen.

Dom

Mutation type

Mis

Other syndrome disease

GATA2

• Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells
• Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
• Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3
• An early haematopoietic defect in mice lacking the transcription factor GATA-2