Medical Knowledge Cockpit eosinophilia

• PI3K-Akt signaling pathway
  Homo sapiens (human) one gene

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PDGFRB

Somatic tumors

MPN, AML, CMML, CML

Tumor types germline

Cancer Syndrom

Translocation partner

ETV6, TRIP11, HIP1, RABEP1, H4, NIN, SPECC1, PDE4DIP

Name

platelet-derived growth factor receptor, beta polypeptide

Chromosome banding

5q31-q32

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

ABL2

• Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro

PDGFRB

• Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
• Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
• Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
• Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
• Blood vessel maturation: vascular development comes of age