Medical Knowledge Cockpit epidermal nevus

 

NRAS

Somatic tumors

melanoma, MM, AML, thyroid

Tumor types germline

Cancer Syndrom

Translocation partner

Name

neuroblastoma RAS viral (v-ras) oncogene homolog

Chromosome banding

1p13.2

Cancer molecular gen.

Dom

Mutation type

Mis

Other syndrome disease

 

NRAS

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasmamembrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factorand inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectalcancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenilemyelomonocytic leukemia. (provided by RefSeq, Jun 2011)

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasmamembrane

This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factorand inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectalcancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenilemyelomonocytic leukemia. (provided by RefSeq, Jun 2011)

NRAS

• Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line