Medical Knowledge Cockpit esophageal carcinoma, somatic

DCC

• Dependence receptors: when apoptosis controls tumor progression

 

DCC

Somatic tumors

CRC, melanoma, SCC

Tumor types germline

Cancer Syndrom

Translocation partner

Name

DCC netrin 1 receptor

Chromosome banding

18q21.2

Cancer molecular gen.

Mutation type

Mis, N, D

Other syndrome disease

 

DCC

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily ofcell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2)to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absenceof ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectalcancer and esophageal carcinoma. (provided by RefSeq, Oct 2009)

This gene encodes a netrin 1 receptor

The transmembrane protein is a member of the immunoglobulin superfamily ofcell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2)to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absenceof ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectalcancer and esophageal carcinoma. (provided by RefSeq, Oct 2009)

 

• DCC mediated attractive signaling
  species not specified one gene

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