Medical Knowledge Cockpit ewing sarcoma

EWSR1

Somatic tumors

Ewing sarcoma, desmoplastic small round cell tumour , ALL, clear cell sarcoma, sarcoma, myoepithelioma, mesothelioma

Tumor types germline

Cancer Syndrom

Translocation partner

FLI1, ERG, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1, PBX1, NFATC1, NFATC2, DDIT3, PATZ1, SMARCA5, SP3, ZNF444, YY1

Name

Ewing sarcoma breakpoint region 1 (EWS)

Chromosome banding

22q12

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

EWSR1

• SRE elements are binding sites for the fusion protein EWS-FLI-1
• Normalization and subtraction: two approaches to facilitate gene discovery
• Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
• Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins