Medical Knowledge Cockpit fanconi anemia, complementation group f

FANCF

• A novel ubiquitin ligase is deficient in Fanconi anemia
• Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival
• The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)
• Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer
• The Fanconi anemia gene product FANCF is a flexible adaptor protein

FANCF

Somatic tumors

Tumor types germline

AML, leukaemia

Cancer Syndrom

Fanconi anaemia F

Translocation partner

Name

Fanconi anemia, complementation group F

Chromosome banding

11p15

Cancer molecular gen.

Rec

Mutation type

N, F

Other syndrome disease