Medical Knowledge Cockpit fanconi anemia, complementation group n

PALB2

• Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2

 

PALB2

Somatic tumors

Tumor types germline

Wilms tumour, medulloblastoma, AML ,breast

Cancer Syndrom

Fanconi anaemia N, breast cancer susceptibility

Translocation partner

Name

partner and localizer of BRCA2

Chromosome banding

16p12.1

Cancer molecular gen.

Rec

Mutation type

F, N, Mis

Other syndrome disease

 

PALB2

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with thebreast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclearlocalization and accumulation of BRCA2. (provided by RefSeq, Jul 2008)

This gene encodes a protein that may function in tumor suppression

This protein binds to and colocalizes with thebreast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclearlocalization and accumulation of BRCA2. (provided by RefSeq, Jul 2008)