Medical Knowledge Cockpit frasier syndrome

WT1

Somatic tumors

Wilms tumour, desmoplastic small round cell tumour

Tumor types germline

Wilms tumour

Cancer Syndrom

Denys-Drash syndrome, Frasier syndrome, familial Wilms tumour

Translocation partner

EWSR1

Name

Wilms tumour 1 gene

Chromosome banding

11p13

Cancer molecular gen.

Rec

Mutation type

D, Mis, N, F, S, T

Other syndrome disease

WT1

• WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
• A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1
• Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9
• Identification of WTAP, a novel Wilms' tumour 1-associating protein