Medical Knowledge Cockpit gastric cancer, somatic

 

• Cleavage of the damaged purine
  species not specified one gene

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• FasL/ CD95L signaling
  species not specified one gene

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• Epstein-Barr virus infection
  Homo sapiens (human) one gene

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• Gab1 signalosome
  species not specified one gene

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• Depurination
  species not specified one gene

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• Apoptotic cleavage of cellular proteins
  species not specified one gene

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• Death Receptor Signalling
  species not specified one gene

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• Recognition and association of DNA glycosylase with site containing an affected purine
  species not specified one gene

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• caspase cascade in apoptosis
  species not specified one gene

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• telomeres telomerase cellular aging and immortality
  species not specified one gene

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• Thyroid cancer
  Homo sapiens (human) one gene

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PIK3CA

Somatic tumors

colorectal, gastric, glioblastoma, breast

Tumor types germline

Cancer Syndrom

Translocation partner

Name

phosphoinositide-3-kinase, catalytic, alpha polypeptide

Chromosome banding

3q26.3

Cancer molecular gen.

Dom

Mutation type

Mis

Other syndrome disease

 

ERBB2

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Thisprotein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bindtightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding andenhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activatedprotein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 ofisoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, includingbreast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encodingdifferent isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008)

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases

Thisprotein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bindtightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding andenhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activatedprotein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 ofisoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, includingbreast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encodingdifferent isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008)

KRAS

• RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor
• The c-K-ras gene and human cancer (review)
• Structure and mechanisms of activation of c-K-ras oncogenes in human lung cancer

APC

• Identification of a link between the tumour suppressor APC and the kinesin superfamily
• APC binds to the novel protein EB1
• Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization

CASP10

• In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

ERBB2

• Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription
• c-erbB-2 gene product directly associates with beta-catenin and plakoglobin
• Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses
• The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins

FGFR2

• Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors

IRF1

• Functional domains of interferon regulatory factor I (IRF-1)
• Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors

KLF6

• Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization

MUTYH

• MUTYH-associated polyposis (MAP)
• Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair

PIK3CA

• Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta
• The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors
• The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
• Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
• The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells