Medical Knowledge Cockpit gastric cancer risk after h. pylori infection

IL1B

• Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene

IL1RN

• The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci

 

IL1B

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced byactivated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety ofcellular activities, including cell proliferation, differentiation, and apoptosis. The induction ofcyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute toinflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine genecluster on chromosome 2. (provided by RefSeq, Jul 2008)

The protein encoded by this gene is a member of the interleukin 1 cytokine family

This cytokine is produced byactivated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety ofcellular activities, including cell proliferation, differentiation, and apoptosis. The induction ofcyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute toinflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine genecluster on chromosome 2. (provided by RefSeq, Jul 2008)

 

• signal transduction through il1r
  species not specified 2 genes

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