Medical Knowledge Cockpit gastric cancer

 

• Osteoclast differentiation
  Homo sapiens (human) 2 genes

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• HIF-1 signaling pathway
  Homo sapiens (human) 2 genes

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• Chemokine signaling pathway
  Homo sapiens (human) 2 genes

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• Measles
  Homo sapiens (human) 2 genes

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• Amoebiasis
  Homo sapiens (human) 2 genes

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• Influenza A
  Homo sapiens (human) 2 genes

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• Chagas disease (American trypanosomiasis)
  Homo sapiens (human) 2 genes

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• Pertussis
  Homo sapiens (human) 2 genes

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• Bacterial invasion of epithelial cells
  Homo sapiens (human) 2 genes

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• Chronic myeloid leukemia
  Homo sapiens (human) 2 genes

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• Renal cell carcinoma
  Homo sapiens (human) 2 genes

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• Progesterone-mediated oocyte maturation
  Homo sapiens (human) 2 genes

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KLF6

Somatic tumors

prostate, glioma

Tumor types germline

Cancer Syndrom

Translocation partner

Name

Kruppel-like factor 6

Chromosome banding

10p15

Cancer molecular gen.

Rec

Mutation type

Mis, N

Other syndrome disease

 

KRAS

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a memberof the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. Thetransforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinousadenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variantsencoding two isoforms that differ in the C-terminal region. (provided by RefSeq, Jul 2008)

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a memberof the small GTPase superfamily

A single amino acid substitution is responsible for an activating mutation. Thetransforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinousadenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variantsencoding two isoforms that differ in the C-terminal region. (provided by RefSeq, Jul 2008)

CDH1

• IQGAP1 and calmodulin modulate E-cadherin function
• Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1
• Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation
• Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly
• Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin

KRAS

• Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma
• Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap
• RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

APC

• Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein
• Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein
• Identification of a link between the tumour suppressor APC and the kinesin superfamily

CASP10

• In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

ERBB2

• Utility of serum HER2 extracellular domain assessment in clinical decision making: pooled analysis of four trials of trastuzumab in metastatic breast cancer
• ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
• Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription
• c-erbB-2 gene product directly associates with beta-catenin and plakoglobin

FGFR2

• Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model

IRF1

• GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1
• Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery

KLF6

• Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization

MUTYH

• MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps
• MUTYH-Associated Polyposis.

PIK3CA

• Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement
• Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C
• Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta
• The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors
• The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf

IL1B

• Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

IL1RN

• Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor