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LRP5
SDHD
SDHAF2
SDHA
TP53
PTEN
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SDHC
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TP53
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, andoligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression oftarget genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such asLi-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multipletranscript variants and isoforms. Additional isoforms have also been shown to result from the use of alternatetranslation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, andoligomerization domains
The encoded protein responds to diverse cellular stresses to regulate expression oftarget genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such asLi-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multipletranscript variants and isoforms. Additional isoforms have also been shown to result from the use of alternatetranslation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)
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