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TP53

Cancer Gene Census     No results

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SDHC

Somatic tumors
Tumor types germline
paraganglioma, pheochromocytoma
Cancer Syndrom
familial paraganglioma
Translocation partner
Name
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Chromosome banding
1q21
Cancer molecular gen.
Rec
Mutation type
Mis, N, F
Other syndrome disease
Definition     No results

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TP53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, andoligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression oftarget genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such asLi-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multipletranscript variants and isoforms. Additional isoforms have also been shown to result from the use of alternatetranslation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, andoligomerization domains

The encoded protein responds to diverse cellular stresses to regulate expression oftarget genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such asLi-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multipletranscript variants and isoforms. Additional isoforms have also been shown to result from the use of alternatetranslation initiation codons (PMIDs: 12032546, 20937277). (provided by RefSeq, Feb 2013)

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Pathways     No results

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  • pten dependent cell cycle arrest and apoptosis
    species not specified one gene
  • Citrate cycle (TCA cycle)
    Homo sapiens (human) 5 genes
  • Pathways in cancer
    Homo sapiens (human) 2 genes
  • p53 signaling pathway
    Homo sapiens (human) 2 genes
  • PI3K-Akt signaling pathway
    Homo sapiens (human) 2 genes
  • Hepatitis B
    Homo sapiens (human) 2 genes