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goiter, multinodular
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MicroRNA (miRNA) Biogenesis
species not specified
one gene
Cancer Gene Census
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DICER1
Somatic tumors
sex cord-stromal tumour, TGCT, embryonal rhabdomyosarcoma, pleuropulmonary blastoma, pituitary blastoma, Wilms tumour, thyroid cancer, other tumour types
Tumor types germline
pleuropulmonary blastoma
Cancer Syndrom
familial pleuropulmonary blastoma or DICER1 syndrome
Translocation partner
Name
dicer 1, ribonuclease type III
Chromosome banding
14q32.13
Cancer molecular gen.
Rec
Mutation type
Mis, F, N
Other syndrome disease
Definition
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PubMed Links
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DICER1
Dicing and slicing: the core machinery of the RNA interference pathway
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
Clinical Trials
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External
International PPB Registry for PPB, DICER1 and Associated Conditions