Medical Knowledge Cockpit hemangioblastoma, cerebellar, somatic

VHL

Somatic tumors

renal, haemangioma, pheochromocytoma

Tumor types germline

renal, haemangioma, pheochromocytoma

Cancer Syndrom

Von Hippel-Lindau syndrome

Translocation partner

Name

von Hippel-Lindau syndrome gene

Chromosome banding

3p25

Cancer molecular gen.

Rec

Mutation type

D, Mis, N, F, S

Other syndrome disease

VHL

• Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel������Lindau tumor suppressor protein
• The von Hippel������Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription
• von Hippel������Lindau tumor suppressor: not only HIF's executioner
• Formation of primary cilia in the renal epithelium is regulated by the von Hippel������Lindau tumor suppressor protein
• The von Hippel������Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma