Medical Knowledge Cockpit hepatocellular carcinoma

TP53

• A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135)
• MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination
• Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
• RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity
• Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53

• JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases
• Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis
• Physical and functional interactions of neuronal growth suppressor necdin with p53
• Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation
• NUMB controls p53 tumour suppressor activity
• ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
• Parc: a cytoplasmic anchor for p53
• Aprataxin, a novel protein that protects against genotoxic stress
• Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions
• Involvement of PIAS1 in the sumoylation of tumor suppressor p53
• The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53
• Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
• Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1
• Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway
• Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways
• PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb
• Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling
• Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
• Regulation of p53 activity in nuclear bodies by a specific PML isoform
• The function of PML in p53-dependent apoptosis
• Proteasome activator PA28���� regulates p53 by enhancing its MDM2-mediated degradation

MET

• Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
• Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
• Activation of Notch-mediated protective signaling in the myocardium
• Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells
• Invasive growth: a MET-driven genetic programme for cancer and stem cells

• Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
• Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
• Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
• Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis
• Hepatocyte growth factor expression in the developing myocardium: evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression
• Met signaling in cardiomyocytes is required for normal cardiac function in adult mice
• Activated Met signalling in the developing mouse heart leads to cardiac disease

AXIN1

• The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

CASP8

• PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis
• Activation of the NF-kappaB pathway by caspase 8 and its homologs
• ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
• cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

CTNNB1

• Association of the APC tumor suppressor protein with catenins
• Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein
• Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
• Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein
• DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95

• Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
• Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
• Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
• Linking beta-catenin to androgen-signaling pathway
• Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells
• Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor
• A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4
• Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis

IGF2R

• Exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution
• Insulin-like growth factor II (IGF-II)
• The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system

PIK3CA

• Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C
• Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta
• The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors
• The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
• Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

AXIN1

Somatic tumors

colorectal, endometrial, prostate, hepatocellular carcinoma, hepatoblastoma, sporadic medulloblastoma

Tumor types germline

Cancer Syndrom

Translocation partner

Name

axin 1

Chromosome banding

16p13.3

Cancer molecular gen.

Rec

Mutation type

D, Mis, N, F, S

Other syndrome disease

• Chronic myeloid leukemia
  Homo sapiens (human) 2 genes

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• p53 signaling pathway
  Homo sapiens (human) 2 genes

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• Renal cell carcinoma
  Homo sapiens (human) 2 genes

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• Measles
  Homo sapiens (human) 2 genes

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• Hepatitis C
  Homo sapiens (human) 2 genes

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• Herpes simplex infection
  Homo sapiens (human) 2 genes

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• Epstein-Barr virus infection
  Homo sapiens (human) 2 genes

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• Toxoplasmosis
  Homo sapiens (human) 2 genes

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• Chagas disease (American trypanosomiasis)
  Homo sapiens (human) 2 genes

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• Degradation of beta-catenin by the destruction complex
  species not specified 2 genes

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• Pancreatic cancer
  Homo sapiens (human) 2 genes

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• Non-small cell lung cancer
  Homo sapiens (human) 2 genes

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• trefoil factors initiate mucosal healing
  species not specified 2 genes

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