Medical Knowledge Cockpit hereditary motor and sensory neuropathy

MFN2

• Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

TFG

• The functional significance of Shc in insulin signaling as a substrate of the insulin receptor
• The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain

TRPV4

• N-((1S)-1-<nowiki/>{[4-((2S)-2-<nowiki/>{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I
• Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

TFG

Somatic tumors

papillary thyroid, ALCL, NSCLC, extraskeletal myxoid chondrosarcoma

Tumor types germline

Cancer Syndrom

Translocation partner

NTRK1, ALK, NR4A3

Name

TRK-fused gene

Chromosome banding

3q11-q12

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

• Pathways in cancer
  Homo sapiens (human) one gene

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