Medical Knowledge Cockpit hyperinsulinemic hypoglycemia

• Regulation of Insulin Secretion
  species not specified 2 genes

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ABCC8

• Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene

KCNJ11

• Molecular cell biology of KATP channels: implications for neonatal diabetes

GCK

• Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase
• Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

INSR

• Insulin interactions with its receptors: experimental evidence for negative cooperativity
• Genotype-phenotype correlation in inherited severe insulin resistance
• Insulin degradation: progress and potential
• Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit

SLC16A1

• Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1
• Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1