Medical Knowledge Cockpit hypoparathyroidism, sensorineural deafness

GATA3

Somatic tumors

breast

Tumor types germline

Cancer Syndrom

Translocation partner

Name

GATA binding protein 3

Chromosome banding

10p15

Cancer molecular gen.

Rec

Mutation type

F, N, S

Other syndrome disease

HDR syndrome (hypoparathyroidism, sensorineural deafness, and renal disease)

GATA3

• Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family
• Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer
• Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
• GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
• Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet